SIF176D Prominence-to-Preeminence (P2PE) STEM Targeted Initiatives Fund.

Immunology and Informatics for Precision ImmunoMedicine (iPRIME) in Cardiovascular Disease.

Project Manager: Coleen McNamara

Approved: November 2021

Project Dates: 3/01/2022 – 2/28/2027

Funding Awarded: $5,500,000

Executive Summary

In collaboration with the Schools of Medicine, Engineering and Applied Science, Nursing, and Data Science, the goal of implement Precision ImmunoMedicine (iPRIME) is to designate UVA as the premier location for targeting the immune-system for research, diagnosis, prognosis and treatment of cardiovascular disease (CVD) using cutting edge technology, advanced clinical imaging, and innovative, sophisticated artificial intelligence. The team has collected substantial data from patient subjects and has the systems in place to recruit and obtain high dimensional immune system and imaging data and clinical outcomes on another 1000 CVD subjects over the next five years. The team has successfully used bioinformatics and machine learning in cohorts to develop algorithms to assist clinical decision making as a proof of concept. Melding all of these data and topics together will lead to fully realizing the potential preeminence for UVA in precision immunomedicine in CVD.