SIF188 GCRI-BN: Grand Challenge Research Investment - Brain and Neuroscience

Approved: Summer 2022

Project Dates: 1/1/2023 – 12/31/2027

Total Funding: $45,000,000

Executive Summary

The Grand Challenges Research Investments are intended to make a substantial difference through large strategic investments—to move the needle and not just fund business as usual. The Grand Challenge in neuroscience’s initial studies will:

  • Investigate why caregivers of Alzheimer’s patients are more likely to develop dementia than their peers who don’t serve as caregivers.
  • Test the capacity for focused ultrasound to help deliver immunological therapies across the brain’s protective barrier.
  • Catalog neurodiversity among the many forms of autism to develop enhanced interventions and educational approaches for students from early childhood onward.
  • Deploy multiple technologies to better understand the brain’s overall circuitry and development.

Three SIF awards are associated with this endeavor: